产品货号：
Z16962
中文名称：
Hamartin/TSC1抗体
英文名称：
Anti-Hamartin/TSC1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Hamartin/TSC1 Antibody |
| 指标别名 | Hamartin;KIAA0243;LAM;TSC;TSC1;tuberous sclerosis 1;Tuberous sclerosis 1 protein |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | TSC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TSC1 antibody was raised against a 15 amino acid synthetic peptide from the middle region of human TSC1.The immunogen is located within amino acids 220 - 270 of TSC1. |
| 计算分子量 | 130kDa |
| 成分 | TSC1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TSC1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes.The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR),an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors.TOR activity is stimulated by Rheb,a member of the Ras superfamily of G-proteins,when the GTP/GDP ratio bound to Rheb is high.Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro,suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity.This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth.A shorter 40kDa isoform of TSC1 has been shown to exist but its function is unknown. |
| Uniprot ID | Q92574 |
| 基因名全称 | Tuberous sclerosis 1 |
| 蛋白名全称 | Tuberous sclerosis 1 |
| 推荐稀释比 | TSC1 antibody can be used for the detection of TSC1 by Western blot at 1μg/mL.Antibody can also be used for immunocytochemistry starting at 2μg/mL.For immunofluorescence start at 2μg/mL.Antibody validated:Western Blot in mouse samples;Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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